One Drink

• any of the following segments comes on:
  • "Check it Out!"
  • "Consider the Following"
  • "Clever Science Trick"
  • "Did You Know That..."
  • "Hey! Look at This!"
  • "Nifty Home Experiment"
  • "Try This"
  • "Way Cool Scientist"
  • or the music video.
• the theme song gets played. Drink again if it's with someone else's name in place of Bill's, like Boris or Candace.
• anyone mentions a "(fill in the blank) of Science!"
• any segment comes on entitled " (fill in the blank) or Not!" (such as "Alive or Not", "Magnetic or Not", etc.)
• anyone says "Science rules!"
• anyone says "Right, Bill..." or "Sure, Bill..."
• the TV-sitcom Mom says, "Richie, eat your crust!"
• anyone goes through the door to Nye Labs. Drink again if it leads directly outside, or they can't get it open on the first try.
• any line or action gets repeated three times (or more) in a row.
• your attention gets called to a pair of safety goggles.
• someone tells you not to try this at home, or suggests that you get a grown-up to help you or do it for you. Drink again if Bill shows up at that point in the experiment as the "grown-up". Drink a third time if the kids doing the experiment exhibit doubts as to whether or not Bill actually counts a grown-up.
• someone wanders by in the background at the lab, doing something not at all related to the experiment.
• the film gets speeded up to get through the time-consuming part of an experiment.
• Pat, the announcer, starts his "Watch it! Careful! Oo! Ah! Ee!" spiel.
• Bill eats, drinks, or licks something in the lab.
• there's a recognizable spoof of a TV show or movie.
• there's a fake ad.
• Bill appears outside the lab in his lab coat and bowtie.
• a kid tells you what a country or locality is famous for.

Two Drinks

• Bill blows something up.
• there's an oblique reference to Seattle (such as Bill wearing a Mariners cap, Bill looking through a telescope and seeing the Seattle skyline, Bill saying, "Here in the Pacific Northwest...")
• anyone mixes baking soda and vinegar for any reason.
• Luna Van Dyne shows up. (Take the drinks just as she says, "It's from a Dutch word meaning...")
• Bill somehow injures himself with a globe (drops it on his foot, bonks himself in the head, etc.)
• Bill dresses in drag (such as Vivian Cupcake).
• Bill sings. (Note: two drinks may not be enough!)
• Bill flounders while explaining something. Drink a third time if he ends with, "Well, you know what I mean..." ("Uh-huh...")
• Bill loses it completely -- repeatedly screaming, wailing, or shouting at the camera at maximum volume (sometimes with echo) for two lines or more...such as "The Absolute Zero Hour". Drink a third time if Pat tries to snap him out of it ("Uh, Bill?...calm down, Bill...")

Chug!

• Bill says the word "sex".
• Bill uses a Macintosh and/or destroys a PC, despite the fact that Microsoft is headquartered in Seattle ("Science rules!")
• the show ends with no outtakes.

The Optional Former Fratboy I-Absolutely-Must-Get-Drunk-Tonight Rule:

• Drink whenever there's a sound effect.